Constrained Consensus TOPology prediction server

Welcome to the Constrained Consensus TOPology prediction server.

Given the amino acid sequence of a putative α-helical transmembrane protein, CCTOP predicts its topology i.e. localization of membrane spanning regions and orientation of segments between them. The prediction is a consensus of 10 different methods enchanced with available structural and experimental information of any homologous proteins in the TOPDB database. CCTOP was tested on a benchmark set containing 170 proteins with known structure and achieved the highest accuracy among state-of-art and consensus methods.

You can find more information how CCTOP works in the description or in the article. A short description about the server can be found in the manual.

You can submit protein sequences here.